Folic acid in doses above 0.1 mg daily may obscure pernicious anemia in that, hematologic remission can occur while neurological manifestations remain progressive.
Those with elevated serum ferritin levels should be extremely cautious in the use of iron supplements. Iron supplements can be highly toxic or lethal to small children.
Iron supplements should be used with extreme caution in those with chronic liver failure, alcoholic cirrhosis, chronic alcoholism and pancreatic insufficiency.
Carbonyl iron requires adequate stomach acid for absorption. Therefore, carbonyl iron should be taken with food and should not be used with antacids.
Iron should be used with caution in those with a history of gastritis, peptic ulcer disease or gastrointestinal bleeding.